Just because I've been curious about the idea myself, I'll throw out my two bits like the newbie so-and-so I am. 2-D remixes have been very interesting to play with, lately. The ultrasound perspective allows for very intricate patterns. Things like, you know Mari0. Playing Portal this way is very different. Doing this with Minecraft seems only natural.
I think it would be really interesting to see a RTS that operated on this principle. The stage is a huge array of carefully placed patches blocks like MineCraft, but in the 2D plane. Now, mining materials means digging through.. As to what's on the other end, the possibilities there are endless.
So how about a game of defend your castle? You build the platforms, You place the enemies you capture and send to the other side. If it can work, and with enough added rules to make it balanced fix the broken bits, playing this online MultiPlayer would be out of sight. It could be done in rounds, or what have you.
Or how about something more traditional? Blocks which cannot be removed form the framework of the level, and the game becomes manipulating the materials you can harvest and apply. And there are the usual puzzle possibilities with the right use of physics. Say, a steam-bomb puzzle, or something. I'm winging this post right now.